Bone and Tissue Biomechanics

 Determining the combined effects of mechanical stimulation and pharmacological agents on the rate and quality of healing of bone fractures and other injuries of the musculoskeletal tissues.

Scope
The objective of the Bone and Soft Tissue Biomechanics Laboratory is to support clinicians who are treating fracture patients by providing better, more cost effective methods for treating fractures, based on scientific evidence.

Using animal modeling as a primary tool, research by the investigators in the Bone and Tissue Biomechanics Laboratory is directed at quantifying the effects of mechanical stimulation (stress, motion, muscle contraction, sequential muscle compression) on the rate and quality of healing of bone and cartilage, and on preventing and treating fracture non-unions.

Current Research
Current projects include:

  • Measurement of blood flow at the fracture site during healing period;
  • Determine the effect of the amount of blood flow on the rate of fracture healing;
  • Improving the method of treatment of adolescent growth plate fractures.

Apparatus
Full equipped hard and soft tissue histology facility:

  • High resolution cat scanner (XCT 3000 pQCT)
  • Small animal surgery facility with vivarium
  • Small bone torsion testing device
  • Soft and Hard tissue histology processing facility

Staff
The Bone and Soft Tissue Biomechanics Laboratory is under the direction of Sang-Hyun Park, Ph.D.

Publications

  1. Park, S.H., O'Connor, K., McKellop, H., Sarmiento, A.: The influence of active shear or compressive motion on fracture healing. J Bone and Joint Surg. 80(A) 6: 868-878, 1998
  2. Park, S.H., Silva, M., Bahk, W.J., McKellop, H., Lieberman, J.: Effect of repeated irrigation and debridement on fracture healing in an animal model, J. Orthop. Res. 20(6): 1197-1204, 2002
  3. Park, S.H., O'Connor, K. McKellop, H.: Interaction between Active Motion and Exogenous Transforming Growth Factor Beta (TGF-b1) during Tibial Fracture Repair, J Orthop Trauma 17(1): 2-10, 2003
  4. Park, S.H., Silva M.:Effect of pneumatic soft tissue compression of fracture healing in an animal model. J Bone Joint Surg 85A(8) 1446-1453, 2003
  5. Park, S.H. and Silva, M.: Neuromuscular Electrical Stimulation Enhances Fracture Healing: Results of an Animal Model. J Orthop Res 22(2) 382-387, 2004
  6. Park, SH. and Silva, M. Intermittent Pneumatic Soft Tissue Compression Changes in Periosteal and Medullary Canal Blood Flow, J Orthop Res.26:570-577, 2008
  7. M. Virk, A. Conduah, SH. Park, N. Liu, O. Sugiyama, A. Cuomo, C. Kang, J. Lieberman. Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model. Bone, 42(5):921-931, 2008
  8. Cadet ER, Vorys GC, Rahman R, Park SH, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. J Orthop Res. 2010 Mar;28(3):308-14

Contact
The laboratory welcomes industry-sponsored projects, as well as collaborations with other academic institutions. For additional information, contact Sang-Hyun Park, Ph.D., email SangHyunPark@mednet.ucla.edu, or telephone             (213) 742-1443